Friday, June 03, 2011

Anti Adhesion Properties of Cranberry Juice on Escherichia Coli

Reduction of Escherichia coli adherence to uroepithelial bladder cells after consumption of cranberry juice: a double-blind randomized placebo-controlled cross-over trial.
World Journal of Urology. 2006 February;24(1):21-7
The aim of this study was to investigate the anti-adherence activity of urine from women after consumption of cranberry juice. This in vivo study involved 20 women who drank different quantities of cranberry juice, up to 750 ml daily. The first urine in the morning was collected and tested for anti-adherence activity of uropathogenic Escherichia coli strains. The consumption of cranberry juice had no influence on the pH of the urine (in the past it was often wrongly hypnotized that cranberry juice acted by lowering the pH of the urine). There was a dose dependant effect of cranberry juice consumption anti-adherence activity. The researchers concluded that cranberry juice consumption provides anti-adherence activity against the tested uropathogenic Escherichia coli strains.

Role of cranberry juice on molecular-scale surface characteristics and adhesion behavior of Escherichia coli.
Biotechnology and Bioengineering. 2006 February 5;93(2):297-305
Cranberry juice is traditionally used for the prevention and treatment of urinary tract infections. Bacteria use fimbriae to adhere to other cells. Escherichia coli uses the fimbriae to adhere to the epithelium of the bladder. In order to investigate the mechanism by which cranberry phytochemicals act the researchers investigated the influence of cranberry on the adhesion to a silicon nitride surface and two Escherichia coli strains: one with fimbriae (P-fimbriated) and without. With an atomic force microscopy, the researchers were able to observe the bacterial surface polymer and adhesion behavior, after exposure to cranberry juice. The adhesion forces decreased and the structure of surface macromolecules were changed on Escherichia coli strain with fimbriae. The change in adhesion was also observed when the highly acidic cranberry juice was neutralized. The study concluded that to neutralized cranberry juice changed the surface of P-fimbriated Escherichia coli.

Anti-Adhesion Properties of Cranberry

Bacterial Adhesion: Cranberries & Urinary Tract Infection [PDF]